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Low-cost microfluidic electrochemical paper-based device to detect glucose

Authors:

W. T. H. Fernando,

University of Colombo, Colombo, LK
About W. T. H.
Department of Chemistry
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H. K. V. S. Jayarathna,

University of Colombo, Colombo, LK
About H. K. V. S.
Department of Chemistry
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M. N. Kaumal

University of Colombo, Colombo, LK
About M. N.
Department of Chemistry
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Abstract

Continuous monitoring of the level of glucose is essential to maintain the health of a diabetic patient. The use of invasive methods to obtain blood samples to detect glucose is the current method, but such methods may not be preferred by patients. Non-invasive methods such as the determination of glucose based on saliva or sweat can be preferred by patients for continuous monitoring. A low-cost electrochemical microfluidic paper-based analytical device (µPAD) suitable to monitor glucose levels using sweat and saliva is introduced. This device is extremely low-cost due to the use of a paper matrix and varnish for the fabrication of paper. Pseudo-reference stainless steel is used with a working electrode anodized using sodium potassium tartrate tetrahydrate for the development of a three-electrode system. Cyclic voltammetric-based analysis of glucose with µPAD produced a linear response in the working range of 1-10 mmol dm-3 with a limit of detection of 0.058 mol dm-3. The detection of diabetic conditions using saliva and sweat is possible using the device by correlating to the blood glucose levels using prior literature data.
How to Cite: Fernando, W.T.H., Jayarathna, H.K.V.S. and Kaumal, M.N., 2022. Low-cost microfluidic electrochemical paper-based device to detect glucose. Journal of Science of the University of Kelaniya Sri Lanka, 15(1), pp.21–33. DOI: http://doi.org/10.4038/josuk.v15i1.8043
Published on 05 Apr 2022.
Peer Reviewed

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